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Preheat oven to 375°F.
Brown the Italian sausage in a skillet and drain excess grease.
In a large mixing bowl, combine the sausage, drained diced tomatoes, spinach & artichoke dip, Italian seasoning, crushed red pepper, onion powder, garlic powder, ¾ of the Alfredo sauce, and 4 oz of the Parmesan cheese.
Spread the remaining ¼ jar of Alfredo sauce evenly over the bottom of a 9x13 baking dish. Fill with a splash of milk, shake, and add to your pan.
Layer oven-ready lasagna noodles, followed by the sausage mixture. Repeat layers, finishing with the meat mixture, for a total of 3 layers.
Top with the remaining 4 oz Parmesan cheese.
Cover tightly with foil and bake for 25 minutes.
Uncover and bake an additional 5 minutes.
Broil for 5 minutes, watching closely, until golden and bubbly.
Let stand 10–15 minutes before slicing.