In a small bowl, mix together all the sauce ingredients. Cover and refrigerate while preparing the rest of the recipe.
In a large skillet over medium heat, cook the ground beef with the salt, pepper, garlic powder, and onion powder. Break it up into crumbles and cook until browned, about 5-7 minutes. Drain any excess grease.
Divide the shredded lettuce among 4 bowls. Top with cooked beef, shredded cheese, diced pickles, diced onions, and cherry tomatoes.
Drizzle the Big Mac sauce over the bowls and serve.
