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Preheat the oven to 350 degrees F (175 degrees C). Grease a 9x13-inch baking pan.
To make the white cake layer: Mix 3 cups flour, milk, white sugar, eggs, baking powder, 2 teaspoons vanilla extract, and salt together in a large bowl until well-combined. Stir in ¼ cup melted butter. Pour batter into the prepared baking pan.
To make the cinnamon layer: Beat 1 cup softened butter, brown sugar, 2 tablespoons flour, and cinnamon together in a large bowl until smooth. Drop by spoonfuls over the batter in the baking pan.
Swirl the top layer into the bottom layer with a knife to create a marble effect.
Bake cake in the preheated oven until a toothpick inserted into the center comes out nearly clean, 25 to 30 minutes.
To make the glaze: Mix confectioners' sugar, milk, and 1 teaspoon vanilla extract in a large bowl until smooth.
Drizzle glaze over warm cinnamon roll cake. Enjoy!