Preheat the oven to 400°F (200°C).
In a large bowl, combine the butternut squash and Brussels sprouts.
Drizzle with olive oil and season with salt, pepper, garlic powder, and onion powder. Toss to coat evenly.
Spread the vegetables in a single layer on a baking sheet.
Roast in the preheated oven for 25-30 minutes, or until tender and caramelized, stirring halfway through.
Remove from the oven and drizzle with balsamic vinegar before serving.