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Arrange a rack in center of oven; preheat to 375°. Grease a 13" x 9" baking dish with butter.
In a large pot of boiling salted water, cook macaroni, stirring occasionally, until al dente, 5 to 6 minutes. Drain.
In a large saucepan over medium heat, melt 1 stick butter. Sprinkle flour over and cook, stirring, until slightly golden and toasty smelling, 2 to 3 minutes.
Pour in milk and whisk until combined. Add mustard powder; season with salt and pepper. Bring to a simmer over medium-high heat and cook, stirring, until sauce starts to thicken, about 2 minutes.
Remove pan from heat and whisk in cheddar, Gruyère, and 1 cup Parmesan until melted and smooth. Stir in macaroni and transfer to prepared dish.
In a small bowl, combine panko, oil, and remaining ½ cup Parmesan. Sprinkle over macaroni; season with more pepper.
Bake mac and cheese until bubbly and golden, 25 to 30 minutes. Let cool 10 minutes.