Preheat the oven to 350°F (175°C) and grease or line a 9×5-inch loaf pan.
In a medium bowl, whisk together the flour, baking powder, baking soda, and salt.
In a large bowl, cream together the butter and sugar until light and fluffy.
Beat in the eggs, one at a time, then stir in the vanilla extract.
Gradually add the dry ingredients to the wet mixture, alternating with the sour cream, and mix until just combined.
Toss the blueberries with 2 tablespoons of flour, then gently fold them into the batter.
Pour the batter into the prepared loaf pan and spread evenly.
Bake for 55-60 minutes or until a toothpick inserted into the center comes out clean.
Let the bread cool in the pan for 10 minutes, then transfer to a wire rack to cool completely.
