Preheat oven to 400°F. Season tilapia with salt, pepper, paprika, thyme, and oregano; arrange fish in a 9x13 baking dish.
In a mixing bowl, whisk together melted butter, garlic, lemon juice, and lemon zest; pour over tilapia.
Bake tilapia for 10 to 12 minutes, or until fish flakes and is fork-tender.
Garnish with pepper flakes, parsley, and lemon slices. Serve.