Our favorite canned pumpkin puree is made by Libby’s . One 15-ounce can of pumpkin puree is more than enough for this recipe. You can transfer the leftover pumpkin to a zipper-lock bag and freeze it for up to a month. If you'd prefer to make your own pumpkin pie spice, use our recipe for Homemade Pumpkin Pie Spice .
Adjust oven rack to middle position and heat oven to 375 degrees. Generously spray 12-cup muffin tin, including top, with baking spray with flour.
FOR THE TOPPING: Combine flour, sugar, pumpkin pie spice, and salt in bowl. Add melted butter and stir until evenly moistened and mixture resembles wet sand; set aside.
FOR THE MUFFINS: Whisk flour, sugar, pumpkin pie spice, baking powder, and salt together in bowl. Whisk pumpkin, melted butter, eggs, milk, and vanilla together in separate bowl. Stir flour mixture into pumpkin mixture until just combined.
Using greased ⅓-cup dry measuring cup, portion heaping ⅓ cup batter into each muffin cup (cups will be filled to rim). Sprinkle topping evenly over batter, about 1 tablespoon per muffin.
Bake muffins until golden brown and toothpick inserted in center comes out with few crumbs attached, 22 to 25 minutes, rotating muffin tin halfway through baking. Let muffins cool in muffin tin on wire rack for 10 minutes. Remove muffins from muffin tin and let cool on rack for 5 minutes. Serve.
