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Heat oven to 400 degrees F.
If using frozen asparagus, defrost and use paper towels to remove excess moisture.
Sprinkle the asparagus and pepperoni pieces over the bottom of the pie crust.
Top with the shredded cheeses.
In a medium bowl, beat the eggs with a whisk until a bit foamy. Stir in the half and half and the Italian spices.
Pour the egg mixture over the filling. Be sure that no part of the cheese is sticking out too high.
Place in oven on the middle rack. Turn the temperature down to 350 degrees F and bake 30-45 minutes until set. The knife should come out clean if stuck in the middle.