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Preheat the oven to 350°F/175C. Lightly grease a 9x13-inch pan.
In a large mixing bowl, knead together the ground beef, onion, bread crumbs, milk, egg, Worcestershire sauce, salt, basil, oregano, pepper, and red pepper flakes.
Shape the meat mixture into a loaf and place it in the prepared pan.
Bake in the preheated oven for 45 minutes.
In a small bowl, whisk together the ketchup, brown sugar, and Worcestershire sauce to prepare the glaze.
Brush the glaze over the hot meatloaf.
Increase the oven temperature to 400°F and bake for an additional 15 minutes or until the meatloaf reaches an internal temperature of 160°F.