Sprinkle yeast over surface of warm water in a large bowl. Let stand for 1 minute, then stir to dissolve. Mix in flour, salt, and olive oil. When dough is too thick to stir, turn out onto a floured surface and knead for 5 minutes. Knead in a little more flour if dough is too sticky. Place into an oiled bowl, cover, and set aside in a warm place to rise until doubled in bulk.
Preheat the oven to 475 degrees F (245 degrees C). If using a pizza stone, preheat it in the oven as well, setting it on the lowest shelf.
When dough has risen, flatten it out on a lightly floured surface. Roll or stretch out into a 12-inch circle, and place on a baking pan. If you are using a pizza stone, you may place it on a piece of parchment while preheating the stone in the oven.
Spread tomato sauce evenly over dough. Sprinkle with oregano, mozzarella cheese, basil, Romano cheese, and red pepper flakes.
Bake for 12 to 15 minutes in the preheated oven, until bottom of crust is browned when you lift up the edge a little, and cheese is melted and bubbly. Cool for about 5 minutes before slicing and serving.
