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Preheat the oven to 425°F.
In a large pot, cook the pasta according to package instructions, then drain thoroughly.
Meanwhile, in a large skillet, brown the Italian sausage with onion and minced garlic over medium-high heat. Drain any excess fat.
Add your choice of pizza toppings (see notes) and cook for 3-4 minutes or until vegetables are tender.
Add drained tomatoes, oregano, Italian seasoning, pizza sauce, and marinara sauce. Simmer for 5 minutes.
Toss the cooked pasta with the sauce and half of the pepperoni slices. Pour the mixture into a greased 9×13 pan.
Top with the mozzarella cheddar blend, the remaining pepperoni and parmesan cheese.
Bake uncovered for 18 to 22 minutes or until the cheese is browned.