Preheat the oven to 250°. Prepare a cookie sheet with parchment paper.
Measure out the pretzels into a large bowl.
Melt and pour the butter over the pretzels. Stir to coat evenly.
In a small bowl, combine the powdered buttermilk, salt, garlic powder, onion powder, cayenne pepper and black pepper. Stir the seasonings together.
Sprinkle the seasonings onto the pretzels while stirring to coat evenly.
Arrange on the prepared cookie sheet in a single layer.
Bake at 250° for 20 minutes. Allow the pretzels to cool before eating.
