Place medium saucepan on stovetop over high heat. When saucepan is warm, add 4 tablespoons unsalted butter, 4 tablespoons red wine, 2 cups low-sodium beef broth, 1 tablespoon Worcestershire sauce, ½ teaspoon onion powder, and ½ teaspoon garlic powder.
Whisk ingredients together until incorporated, then bring mixture to boil. Once mixture begins to boil, reduce heat under saucepan to medium-low. Simmer mixture 5 minutes.
After 5 minutes, taste mixture and add ½ teaspoon salt, onion powder, and/or garlic as desired. When satisfied with flavor, transfer au jus into serving container.
Serve warm with prime rib, French dip sandwiches, roast beef, or other meal as desired.
