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Preheat oven to 375°F. Lightly spray a 9x13-inch dish with cooking spray.
Slice each biscuit in half with a serrated knife. (You will have 2 round pieces) Place biscuit bottoms in the baking dish. Sprinkle half of the ham over the biscuits and top with half of the cheese. Place remaining biscuits on top of the cheese and cover with remaining ham and cheese.
Whisk together eggs, milk, cream, honey mustard dressing, onion powder, garlic powder, salt, and black pepper in a medium bowl. Pour egg mixture over biscuits. (Can cover and refrigerate at this point)
Bake for 50 to 60 minutes, until eggs are set. Cover the casserole dish with aluminum foil if it starts to get too brown.
Let casserole stand 10 minutes before serving.