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Preheat the oven to 350 degrees and line a baking sheet with parchment paper.
Stir together the melted butter, Italian seasoning, and garlic powder in a small bowl. Set aside.
Arrange 30 crackers on the prepared baking sheet.
Top each cracker with a slice of pepperoni and a slice of cheese. Place another cracker on top.
Brush the crackers with the butter mixture.
Place in the preheated oven and bake for 10 to 15 minutes, until the cheese is melted.
Serve immediately.