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Preheat the oven to 375°F. Grease a 1 ½ to 2-quart baking dish, or an 8" or 9" cast-iron skillet or cake pan that's at least 1 ½" deep.
In a large bowl, stir together the flour, sugar, salt, baking soda, and baking powder.
In a smaller bowl, whisk together the buttermilk, egg, and melted butter or oil.
Make a well in the dry ingredients and pour in the liquids. Stir together until blended and no dry spots remain; the dough will be soft and sticky.
Scoop the dough into the prepared pan, mounding it in the center. Brush the top with the melted butter. Wait 5 minutes for liquid to be absorbed by the flour before baking.
Bake the bread for 35 to 45 minutes, or until it tests done (a cake tester inserted into the center will come out clean). Remove it from the oven, and serve warm.