Preheat the oven to 425°F.
Line a rimmed baking sheet with parchment paper. Spray the parchment paper with oil.
Wash and dry the sprouts. Remove any damaged outer leaves. Cut them in half.
Place the Brussels sprouts in a large bowl. Add the melted butter, honey, salt, pepper, and garlic powder. Use a large spoon or your hands to coat the sprouts evenly and thoroughly.
Arrange the sprouts in a single layer on the prepared baking sheet. Roast them for 15 minutes.
Remove the pan from the oven. Flip the sprouts to the other side. If any of them is already deeply browned, remove it to a plate. Wipe off any spots with caramelized honey on the pan to prevent them from burning.
Return the pan to the oven and roast the sprouts until tender and browned, for 10-15 more minutes.
Serve immediately.
