In a bowl, combine scallops, olive oil, paprika, garlic powder, salt, pepper, and cayenne pepper (if using). Toss to coat. Let the scallops marinate for at least 30 minutes, or up to 24 hours.
Heat a large skillet over medium-high heat. Sear scallops for 2-3 minutes per side, or until golden brown and cooked through.
Whisk together mayonnaise, sour cream, Cajun seasoning, lemon juice, Worcestershire sauce, and hot sauce (if using) in a small bowl.
Spoon Creamy Cajun Sauce onto plates. Top with seared scallops and enjoy!
