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Heat a large skillet over medium-high heat. Cook and stir ground beef, onion, garlic powder, onion powder, salt, and black pepper in the hot skillet until beef is browned and crumbly, 5 to 7 minutes; drain and discard grease.
Increase heat to high. Add water to ground beef mixture in the skillet. Cover and bring to a boil. Stir macaroni into boiling water-ground beef mixture. Cover, lower heat to medium, and cook for 5 minutes. Stir, cover, and continue cooking until macaroni is tender, about 5 minutes.
Stir processed cheese food into ground beef-macaroni mixture until melted. Remove from heat; stir in sour cream.