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Gather all ingredients.
Mix buttermilk, water, salt, and pepper in a small bowl. Pour mixture into a flat pan large enough to hold fillets.
Arrange fillets in a single layer in the pan, turning to coat each side. Set aside to marinate.
Combine cornmeal, flour, and seafood seasoning in a 2-gallon resealable plastic bag.
Add fillets to the bag, a few at a time, and tumble gently until evenly coated.
Heat oil in a deep fryer to 365 degrees F (185 degrees C). Fry fillets in hot oil until crisp and golden brown, about 3 minutes. Work in batches to avoid overcrowding, so fillets have room to brown properly.
Drain on paper towels.
Serve and enjoy!