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Season tilapia fillets with salt, pepper, paprika, and garlic powder.
Place the flour onto a plate or shallow baking dish and then dredge each filet in the flour to lightly coat both sides of the fish. Shake off any excess flour from the filets.
Heat the olive oil and butter in a skillet over medium-high heat and cook the filets for 2 to 3 minutes per side, until golden brown.
Garnish with a squeeze of lemon juice and chopped parsley.