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Preheat your oven to 350°F and take a moment to whisper a word of thanks for the hands that will enjoy the meal you’re about to prepare.
In a large mixing bowl, combine the ground beef, breadcrumbs, milk, eggs, onion, garlic, parsley, oregano, salt, and pepper. Gently combine these with your hands—but don’t overwork it now; we’re making meatloaf, not a brick.
Lay half of the meat mixture in a line down the center of a greased loaf pan.
Nestle the cheese snugly in the center, leaving a meaty border all around.
Cover the cheese with the remaining meat mixture, pressing the edges to seal the cheese like a precious gift under a Christmas tree.
Stir together the ketchup, brown sugar, and mustard to make a tangy glaze and pour this over the meatloaf, spreading it around evenly.
Bake for about 1 hour and 15 minutes, or until the meatloaf is no longer pink in the center. Let it sit and rest for 10 minutes; good things come to those who wait.
Slice and serve, and watch as the cheese, like a well-kept secret, spills out to the delight of your diners.