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Preheat the oven to 350 degrees F (175 degrees C) and spray a 9x13-inch baking or casserole dish with nonstick cooking spray.
Set a large skillet over medium-high heat. Once hot, add the ground beef and cook, stirring and breaking up with a spoon, until no longer pink, about 8 minutes. Season to taste with salt and pepper; stir in garlic powder and crushed red pepper, if using.
Cover the bottom of the prepared baking dish with sliced potatoes and season well with salt and pepper (and add butter, if using). Top with the cooked ground beef then sliced onions. Season with salt and pepper, then the diced tomatoes and the bell peppers. Cover with foil and bake for 2 hours.