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Preheat oven to 400F. Combine the cauliflower florets in a large bowl with the aquafaba or broth and sprinkle with salt and pepper to taste. Mix well. Line a baking sheet with parchment paper and spread the cauliflower on it. Bake for about 15 minutes, until a little tender and beginning to brown on the edges. Stir in the garlic and bake for another minute. Remove from oven and set aside.
While the cauliflower is roasting, cook the macaroni in salted water according to package directions. Drain well and return to the pot. Add the cauliflower to the pot once it is done.
Place all sauce ingredients in a blender and blend until combined. Pour the sauce over the macaroni and cauliflower. Cook over medium-high heat, stirring often and scraping the bottom, until sauce boils and thickens. Sauce should be very thick.
Check the seasoning and add more salt, pepper, or other spices to taste. You may serve the macaroni at this point or add a topping and bake it as a casserole.
Preheat oven to 375F. Pour the mac and cheese into a medium-sized casserole dish (the one I used was 6 ½ x 10 x 2-inches tall.) Combine the topping ingredients and spread it evenly over the top. Bake for about 10 minutes, until top is lightly browned in places. Serve hot, garnished with fresh oregano leaves if you desire.