Preheat your oven to 350°F (175°C).
In a medium mixing bowl, combine the ketchup and barbecue sauce, then set aside.
In a large mixing bowl, add the ground beef. Crush the Ritz crackers and add the crumbs to the ground beef. Add the Lipton onion soup mix and eggs to the mixture. Pour in ½ cup of the ketchup and barbecue sauce mixture. Mix all ingredients together until fully combined and press into a greased 9×13 inch baking dish.
Spread the remaining ketchup and barbecue sauce mixture on top of the meatloaf and bake for 30 minutes.
While the meatloaf is baking, cook the macaroni noodles according to the package directions, then drain.
In a large mixing bowl, whisk together the milk and condensed cheddar cheese soup until no lumps remain. Add the salt, pepper, garlic powder, and onion powder, then stir in the cooked macaroni noodles and 2 cups of the shredded cheese.
Once the meatloaf has baked for 30 minutes, remove it from the oven. Pour the macaroni mixture on top of the meatloaf and spread it out evenly. Sprinkle the remaining 2 cups of shredded cheese on top.
Return the dish to the oven and bake for an additional 17-20 minutes, or until the cheese on top is fully melted and just starting to brown.
Let the casserole sit for a few minutes before slicing and serving.