Gather all ingredients.
Combine ketchup, brown sugar, red wine vinegar, Dijon-style mustard, Worcestershire sauce, and liquid smoke.
Stir in salt, pepper, garlic powder, onion powder, chili powder, and cayenne.
Place chuck roast in a slow cooker. Pour ketchup mixture over chuck roast. Cover and cook on Low for 8 to 10 hours.
Remove chuck roast from slow cooker, shred with a fork, and return to the slow cooker.
Stir meat to evenly coat with sauce. Continue cooking for approximately 1 hour more.
Serve and enjoy!
