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Melt the butter and then add garlic powder, paprika, salt, and pepper. Mix well and set aside.
Place the shrimp into a large casserole dish. Pour half of the seasoned butter on top and mix well. Then arrange the shrimp in an even layer.
Add the Panko breadcrumbs to the remaining butter and stir well to combine.
Sprinkle the buttered breadcrumbs over the shrimp. Bake at 375°F for 12 minutes. If desired, broil for 1-2 minutes, allowing the breadcrumbs to brown a bit more.
Garnish with fresh parsley and serve with lemon wedges. Enjoy!